Oleanane triterpenes from the flowers of Camellia japonica inhibit porcine epidemic diarrhea virus (PEDV) replication.
Identifieur interne : 001272 ( Main/Exploration ); précédent : 001271; suivant : 001273Oleanane triterpenes from the flowers of Camellia japonica inhibit porcine epidemic diarrhea virus (PEDV) replication.
Auteurs : Jun-Li Yang [Corée du Sud] ; Thi-Kim-Quy Ha ; Basanta Dhodary ; Euisun Pyo ; Ngoc Hieu Nguyen ; Hyomoon Cho ; Eunhee Kim ; Won Keun OhSource :
- Journal of medicinal chemistry [ 1520-4804 ] ; 2015.
Descripteurs français
- KwdFr :
- Acide oléanolique (), Acide oléanolique (analogues et dérivés), Acide oléanolique (isolement et purification), Acide oléanolique (pharmacologie), Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Camellia (), Conformation moléculaire, Fleurs (), Relation dose-effet des médicaments, Relation structure-activité, Réplication virale (), Tests de sensibilité microbienne, Virus de la diarrhée porcine épidémique (), Virus de la diarrhée porcine épidémique (croissance et développement).
- MESH :
- analogues et dérivés : Acide oléanolique.
- croissance et développement : Virus de la diarrhée porcine épidémique.
- isolement et purification : Acide oléanolique, Antiviraux.
- pharmacologie : Acide oléanolique, Antiviraux.
- Acide oléanolique, Antiviraux, Camellia, Conformation moléculaire, Fleurs, Relation dose-effet des médicaments, Relation structure-activité, Réplication virale, Tests de sensibilité microbienne, Virus de la diarrhée porcine épidémique.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Camellia (chemistry), Dose-Response Relationship, Drug, Flowers (chemistry), Microbial Sensitivity Tests, Molecular Conformation, Oleanolic Acid (analogs & derivatives), Oleanolic Acid (chemistry), Oleanolic Acid (isolation & purification), Oleanolic Acid (pharmacology), Porcine epidemic diarrhea virus (drug effects), Porcine epidemic diarrhea virus (growth & development), Structure-Activity Relationship, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Oleanolic Acid.
- chemical , chemistry : Antiviral Agents, Oleanolic Acid.
- chemical , isolation & purification : Antiviral Agents, Oleanolic Acid.
- chemical , pharmacology : Antiviral Agents, Oleanolic Acid.
- chemistry : Camellia, Flowers.
- drug effects : Porcine epidemic diarrhea virus, Virus Replication.
- growth & development : Porcine epidemic diarrhea virus.
- Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Molecular Conformation, Structure-Activity Relationship.
Abstract
Porcine epidemic diarrhea virus (PEDV) infections have resulted in a severe economic loss in the swine industry in many countries due to no effective treatment approach. Fifteen oleanane triterpenes (1-15), including nine new ones (1-4 and 10-14), were isolated from the flowers of Camellia japonica, and their molecular structures were determined by extensive spectroscopic methods. These compounds were evaluated for their antiviral activity against PEDV replication, and the structure-activity relationships (SARs) were discussed. Compounds 6, 9, 11, and 13 showed most potent inhibitory effects on PEDV replication. They were found to inhibit PEDV genes encoding GP6 nucleocapsid, GP2 spike, and GP5 membrane protein synthesis based on RT-PCR data. Western blot analysis also demonstrated their inhibitory effects on PEDV GP6 nucleocapsid and GP2 spike protein synthesis during viral replication. The present study suggested the potential of compounds 6, 9, 11, and 13 as promising scaffolds for treating PEDV infection via inhibiting viral replication.
DOI: 10.1021/jm501567f
PubMed: 25568928
Affiliations:
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Le document en format XML
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Camellia japonica inhibit porcine epidemic diarrhea virus (PEDV) replication.</title><author><name sortKey="Yang, Jun Li" sort="Yang, Jun Li" uniqKey="Yang J" first="Jun-Li" last="Yang">Jun-Li Yang</name><affiliation wicri:level="1"><nlm:affiliation>Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Sillim-dong, Gwanak-gu, Seoul 151-742</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ha, Thi Kim Quy" sort="Ha, Thi Kim Quy" uniqKey="Ha T" first="Thi-Kim-Quy" last="Ha">Thi-Kim-Quy Ha</name></author><author><name sortKey="Dhodary, Basanta" sort="Dhodary, Basanta" uniqKey="Dhodary B" first="Basanta" last="Dhodary">Basanta Dhodary</name></author><author><name sortKey="Pyo, Euisun" sort="Pyo, Euisun" uniqKey="Pyo E" first="Euisun" last="Pyo">Euisun Pyo</name></author><author><name sortKey="Nguyen, Ngoc Hieu" sort="Nguyen, Ngoc Hieu" uniqKey="Nguyen N" first="Ngoc Hieu" last="Nguyen">Ngoc Hieu Nguyen</name></author><author><name sortKey="Cho, Hyomoon" sort="Cho, Hyomoon" uniqKey="Cho H" first="Hyomoon" last="Cho">Hyomoon Cho</name></author><author><name sortKey="Kim, Eunhee" sort="Kim, Eunhee" uniqKey="Kim E" first="Eunhee" last="Kim">Eunhee Kim</name></author><author><name sortKey="Oh, Won Keun" sort="Oh, Won Keun" uniqKey="Oh W" first="Won Keun" last="Oh">Won Keun Oh</name></author></analytic><series><title level="j">Journal of medicinal chemistry</title><idno type="eISSN">1520-4804</idno><imprint><date when="2015" 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xml:lang="en"><term>Antiviral Agents</term><term>Oleanolic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Oleanolic Acid</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide oléanolique</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Camellia</term><term>Flowers</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Virus de la diarrhée porcine épidémique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Porcine epidemic diarrhea virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Porcine epidemic diarrhea virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Acide oléanolique</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide oléanolique</term><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term><term>Microbial Sensitivity Tests</term><term>Molecular Conformation</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide oléanolique</term><term>Antiviraux</term><term>Camellia</term><term>Conformation moléculaire</term><term>Fleurs</term><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Réplication virale</term><term>Tests de sensibilité microbienne</term><term>Virus de la diarrhée porcine épidémique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Porcine epidemic diarrhea virus (PEDV) infections have resulted in a severe economic loss in the swine industry in many countries due to no effective treatment approach. Fifteen oleanane triterpenes (1-15), including nine new ones (1-4 and 10-14), were isolated from the flowers of Camellia japonica, and their molecular structures were determined by extensive spectroscopic methods. These compounds were evaluated for their antiviral activity against PEDV replication, and the structure-activity relationships (SARs) were discussed. Compounds 6, 9, 11, and 13 showed most potent inhibitory effects on PEDV replication. They were found to inhibit PEDV genes encoding GP6 nucleocapsid, GP2 spike, and GP5 membrane protein synthesis based on RT-PCR data. Western blot analysis also demonstrated their inhibitory effects on PEDV GP6 nucleocapsid and GP2 spike protein synthesis during viral replication. The present study suggested the potential of compounds 6, 9, 11, and 13 as promising scaffolds for treating PEDV infection via inhibiting viral replication. </div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Cho, Hyomoon" sort="Cho, Hyomoon" uniqKey="Cho H" first="Hyomoon" last="Cho">Hyomoon Cho</name><name sortKey="Dhodary, Basanta" sort="Dhodary, Basanta" uniqKey="Dhodary B" first="Basanta" last="Dhodary">Basanta Dhodary</name><name sortKey="Ha, Thi Kim Quy" sort="Ha, Thi Kim Quy" uniqKey="Ha T" first="Thi-Kim-Quy" last="Ha">Thi-Kim-Quy Ha</name><name sortKey="Kim, Eunhee" sort="Kim, Eunhee" uniqKey="Kim E" first="Eunhee" last="Kim">Eunhee Kim</name><name sortKey="Nguyen, Ngoc Hieu" sort="Nguyen, Ngoc Hieu" uniqKey="Nguyen N" first="Ngoc Hieu" last="Nguyen">Ngoc Hieu Nguyen</name><name sortKey="Oh, Won Keun" sort="Oh, Won Keun" uniqKey="Oh W" first="Won Keun" last="Oh">Won Keun Oh</name><name sortKey="Pyo, Euisun" sort="Pyo, Euisun" uniqKey="Pyo E" first="Euisun" last="Pyo">Euisun Pyo</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Yang, Jun Li" sort="Yang, Jun Li" uniqKey="Yang J" first="Jun-Li" last="Yang">Jun-Li Yang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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